Topisal 6% Lotion is a topical medicine composed of Clobetasol and Salicylic acid. It is used to manage symptoms of psoriasis, which is a skin condition that causes red, itchy scaly patches, most commonly on the knees, elbows, trunk and scalp. This medicine works by reducing the production of chemical transmitters responsible for swelling and itching. Topisal 6% Lotion can cause side effects like exfoliation of skin (removal of dead skin) and redness at the applied site. Most of these side effects are temporary and resolve on their own. Consult your doctor if these side effects are persistent or worsen.